Rybelsus is the oral form of semaglutide, taken once daily instead of by injection. Just like with injected GLP-1 medications, it’s important to build up the dose gradually. This allows your body to adjust to the active ingredient and helps reduce the likelihood of side effects such as nausea or stomach discomfort.
The dosage is typically increased every 30 days—if well tolerated—to achieve optimal results with minimal side effects. Here’s how the standard dosage progression works:
Rybelsus dosage schedule
Week 1–4: 3 mg once daily
This is the starting dose, designed to help your body get used to semaglutide. While the 3 mg dose is not considered therapeutic, it’s an important first step in preparing your system for higher doses.
Some individuals already begin to feel a slight reduction in appetite or less intense cravings during this phase.
Goal: Allow your digestive system to adjust and reduce the chance of side effects as you move to higher doses.
Week 5–8: 7 mg once daily
After the first month, the dosage is typically increased to 7 mg per day. This is the first active dose that supports appetite regulation and weight loss.
Many people begin to experience clearer effects on their hunger levels, satiety, and possibly some early weight changes.
Goal: Begin activating the full GLP-1 effect to support weight loss and appetite control.
Week 9 and beyond: 14 mg once daily
If you tolerate 7 mg well and further results are desired, the dose may be increased to the maximum approved dose of 14 mg. This level delivers the strongest clinical benefits in terms of appetite suppression, blood sugar regulation, and weight loss.
Goal: Maximize the effect of Rybelsus on appetite and metabolism for sustainable long-term results.
Consultation and next steps
Rybelsus should always be taken on an empty stomach, with no food or drink (other than water) for at least 30 minutes afterward—this ensures proper absorption of the medication.
Before making any dose changes, check in with your Vi-Lifestyle medical team. We’ll evaluate your progress, review any side effects, and help determine the safest and most effective next step.
We’ll also keep you informed of any cost differences between dosage levels, so you can make confident and informed choices about your treatment.